Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility
| Autor: | Ulrik Stoltze, Michael D. Swartz, Virginia Perez-Andreu, Nalini Ranjit, Ting Nien Lin, Cesar R. Najera, Charnise Goodings, Philip J. Lupo, Pedro A. de Alarcon, Sharon E. Plon, Ryan C. Zabriskie, Natalie P. Archer, Karen R. Rabin, Anna V. Wilkinson, Erin C. Peckham-Gregory, Maoxiang Qian, Jun J. Yang, Michael E. Scheurer, Federico Antillon-Klussmann |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology Heredity Epidemiology Ethnic group lcsh:Medicine Genome-wide association study Hematologic Cancers and Related Disorders Native Americans Medicine and Health Sciences Ethnicities Exome Child lcsh:Science Hispanic People education.field_of_study Multidisciplinary Genomics Hematology Hispanic or Latino Precursor Cell Lymphoblastic Leukemia-Lymphoma Acute Lymphoblastic Leukemia Guatemala Texas DNA-Binding Proteins Genetic Mapping Child Preschool Lymphoblastic Leukemia Female Research Article medicine.medical_specialty Adolescent Genotype Population Variant Genotypes Single-nucleotide polymorphism Population stratification Polymorphism Single Nucleotide Ethnic Epidemiology 03 medical and health sciences Internal medicine Leukemias Genome-Wide Association Studies Genetics medicine Humans Genetic Predisposition to Disease education Childhood Acute Lymphoblastic Leukemia Alleles Genetic Association Studies Genetic association Evolutionary Biology Population Biology business.industry lcsh:R Infant Newborn Biology and Life Sciences Computational Biology Cancers and Neoplasms Infant Human Genetics Genome Analysis 030104 developmental biology People and Places Population Groupings lcsh:Q business Population Genetics Genome-Wide Association Study Transcription Factors |
| Zdroj: | PLoS ONE, Vol 12, Iss 8, p e0180488 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0180488 |
| Popis: | We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710 individuals from 323 Guatemalan and US Hispanic families, two inherited SNPs in ARID5B reached genome-wide level significance: rs10821936, RR = 2.31, 95% CI = 1.70–3.14, p = 1.7×10−8 and rs7089424, RR = 2.22, 95% CI = 1.64–3.01, p = 5.2×10−8. Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63–3.02, p = 9.63×10−8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57–2.88, p = 2.81×10−7. Notably, effect sizes observed for rs7089424 and rs10821936 in our study were >20% higher than those reported among non-Hispanic white populations in previous genetic association studies. Our results confirmed the role of ARID5B in childhood ALL susceptibility among Hispanics; however, our assessment did not reveal any strong novel inherited genetic risks for acute lymphoblastic leukemia among this ethnic group. |
| Databáze: | OpenAIRE |
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