Arachidonic acid and arachidonoyl-diglycerols increase in rat cerebrum during bicuculline-induced status epilepticus
| Autor: | Rodriguez de Turco Eb, Morelli de Liberti Sa, Nicolas G. Bazan |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Phospholipid Status epilepticus Arachidonic Acids Bicuculline Biochemistry Glycerides Diglycerides Cellular and Molecular Neuroscience chemistry.chemical_compound Seizures medicine Animals Phosphatidylinositol chemistry.chemical_classification Cerebral Cortex Arachidonic Acid Cerebrum Fatty Acids Fatty acid Rats Inbred Strains General Medicine Rats medicine.anatomical_structure chemistry lipids (amino acids peptides and proteins) Arachidonic acid Composition (visual arts) medicine.symptom medicine.drug |
| Zdroj: | Neurochemical research. 7(7) |
| ISSN: | 0364-3190 |
| Popis: | Bicuculline-induced status epilepticus was found to be associated with increased amounts of free fatty acids and diacylglycerols in the rat cerebrum. The predominant fatty acid in both lipid pools was arachidonic acid. The accumulation of arachidonoyl-diglycerols decreased at the time of and during behavioral seizures induced by bicuculline, while the amount of free arachidonic acid appeared to increase. We propose a metabolic relationship between these lipids to explain the described changes. The similarities between the composition of the lipid pools and the fatty acid composition of phosphatidylinositol support the hypothesis that these changes may be a result of a convulsion-activated degradation of this phospholipid from excitable membranes. |
| Databáze: | OpenAIRE |
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