Nigella sativa , a traditional Tunisian herbal medicine, attenuates bleomycin-induced pulmonary fibrosis in a rat model
| Autor: | Alexandre Legrand, Saloua Ben Khamsa, Nadia Kourda, Anouar Abidi, Alexandre Robbe |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Herbal Medicine Pulmonary Fibrosis Urinary system Nigella sativa Pharmacology Bleomycin law.invention Transforming Growth Factor beta1 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Fibrosis Pulmonary fibrosis Animals Medicine Carnitine Rats Wistar Lung Inflammation Plants Medicinal Plant Extracts business.industry General Medicine medicine.disease Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Medicine Traditional business Phytotherapy Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 90:626-637 |
| ISSN: | 0753-3322 |
| Popis: | The present study investigated the effects of Nigella sativa oil (NSO) on bleomycin (BLM)-induced lung fibrosis in rats. The rat model of pulmonary fibrosis (PF) was established by intratracheal instillation of BLM, and the effect of 1ml/kg oral NSO treatment once daily observed. The effect of NSO was studied over a period of 50daysusing 1H RMN analysis on the urine and broncho alveolar lavage fluid (Balf) of the rats. Histopathological (inflammation and fibrosis) and immunohistochemical (TGF-β1 density) changes were evaluated. Results found that the BLM group showed a significant increase in inflammatory index (II), fibrosis score (FS) and TGF-β1 distribution in the lung inflammatory infiltrate, accompanied by a decreased urinary secretion of Krebs cycle intermediates, including acetate, pyruvate, carnitine, trimethylamine-N-oxide and succinate. However, at the same time point, NSO treated rats had a reduced II and FS, and had an increased urinary secretion of histidine, fumarate, allantoin and malate. In conclusion, NSO treatment attenuated the effects of BLM-induced PF, by supporting lung, liver and kidney activity in resisting PF. These findings provide an insight into the preventive and therapeutic potential of NSO in the treatment of PF. |
| Databáze: | OpenAIRE |
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