A 4-year prospective evaluation of protocols to improve clinical outcomes for patients with lymphangioleiomyomatosis in a national clinical centre
| Autor: | Rupesh Bhatt, Simon R. Johnson, Janet Bee, Ian McCafferty |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Angiomyolipoma Prospective evaluation Clinical Protocols hemic and lymphatic diseases Medicine Humans Lymphangioleiomyomatosis Intensive care medicine Quality Indicators Health Care business.industry TOR Serine-Threonine Kinases Pneumothorax Targeted interventions respiratory system medicine.disease Prognosis respiratory tract diseases Multisystem disease Surgery Respiratory Function Tests Treatment Outcome Female business |
| Zdroj: | Thorax. 70(12) |
| ISSN: | 1468-3296 |
| Popis: | Lymphangioleiomyomatosis (LAM) is a rare multisystem disease. Progressive airflow limitation, pneumothorax and angiomyolipoma-related bleeding are major morbidities. As treatments are available for these complications, we prospectively audited loss of FEV1 (ΔFEV1), pneumothorax and angiomyolipoma bleeding against clinical standards over 4 years at the UK Clinical Centre. ΔFEV1 for these patients is lower than previously reported and rates of pneumothorax and angiomyolipoma haemorrhage are low. This suggests that real-time analysis of clinical data with targeted interventions can reduce morbidity in LAM. These measures could be applied as quality standards to compare the emerging LAM clinical networks worldwide. |
| Databáze: | OpenAIRE |
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