Phase II study on breast conservative surgery plus chemo- and radiotherapy in treating Chinese patients with early staged breast cancer
| Autor: | Fei Gao, Xiao-Xiang Yin, Ying Zhao, Yang-Chen Liu, Xin-En Huang, Shao-Bing Zhou |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Epidemiology medicine.medical_treatment Postoperative radiotherapy Phases of clinical research Breast Neoplasms Adenocarcinoma Mastectomy Segmental Breast cancer Antineoplastic Combined Chemotherapy Protocols medicine Humans Stage (cooking) Mastectomy Aged Neoplasm Staging Chemotherapy business.industry Carcinoma Ductal Breast Public Health Environmental and Occupational Health Middle Aged medicine.disease Prognosis Combined Modality Therapy Surgery Radiation therapy Survival Rate Carcinoma Lobular Breast conservative surgery Oncology Total dose Lymphatic Metastasis Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 14(6) |
| ISSN: | 2476-762X |
| Popis: | Purpose: To evaluate the efficacy of conservative surgery plus chemo-, radio-therapy in treating patients with early stage breast cancer. Patients and Methods: Eligible patients were treated by postoperative chemotherapy as well as whole-breast irradiation with tumor bed boost. Postoperative radiotherapy consisted of 6 MV whole breast linear accelerator irradiation with two tangential half fields to a total dose of 45~50 Gy, followed by 10~15MeVβ boost irradiation to tumor bed for 10~20Gy, total dose 56~66Gy. Results: Fifty-two patients were enrolled. Overall 1-, 2- and 3 year survival rates were 98.1%, 92.3%, and 90.4%, respectively, with a local recurrence rate of 5.77%. Cosmetic results were evaluated as good by doctors in 90.4% of patients. Conclusions: Breast conservative surgery combined with chemo- radio-therapy could be a treatment option for Chinese patients with early stage breast cancer. |
| Databáze: | OpenAIRE |
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