Reactive oxygen species extend insect life span using components of the insulin-signaling pathway
| Autor: | Tao Wang, Xiao-Shuai Zhang, Xian-Wu Lin, David L. Denlinger, Wei-Hua Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Protein-Arginine N-Methyltransferases Insecta Proto-Oncogene Proteins c-akt medicine.medical_treatment Longevity Diapause Moths Methylation 03 medical and health sciences Commentaries Botany medicine Animals Insulin Protein kinase B chemistry.chemical_classification Reactive oxygen species Multidisciplinary biology fungi Pupa Forkhead Transcription Factors Cell biology Repressor Proteins Insulin receptor 030104 developmental biology chemistry PNAS Plus biology.protein Phosphorylation Signal transduction Reactive Oxygen Species Signal Transduction |
| Popis: | Significance Oxidative damage is frequently associated with aging and aging-related disease, but, paradoxically, several recent studies have shown that artificial boosts of reactive oxygen species (ROS) can also extend life span in young individuals. Here, we show that physiological levels of ROS promote diapause, thereby extending life span in pupae of the moth Helicoverpa armigera. Insect diapause, like the dauer stage of nematodes, is a period of developmental rest that results in a profound extension of life span. ROS appears to contribute to this life span extension by acting through components of the insulin-signaling pathway. Our results thus suggest a new molecular mechanism regulating life span and help to explain the dual nature of ROS action in animals. |
| Databáze: | OpenAIRE |
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