Correlation of aggregometry responses to changes in light transmission through platelet packs
| Autor: | B Edlund, C Sollen, O Berseus, P Järemo |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Light Platelet Aggregation Ionophore chemistry.chemical_element Calcium chemistry.chemical_compound Microcomputers Internal medicine Lactate dehydrogenase medicine Extracellular Methods Humans Platelet Blood Specimen Collection Hematology Hydrogen-Ion Concentration Epinephrine Endocrinology chemistry Immunology Arachidonic acid Platelet factor 4 medicine.drug |
| Zdroj: | Thrombosis research. 62(3) |
| ISSN: | 0049-3848 |
| Popis: | The transmission of light through 22 platelet packs was monitored during storage with a specially designed apparatus in order to estimate the quality of the platelet concentrates without risking contamination. The changes in light transmission during a 7 day storage period were compared with other properties of platelets upon day 1 and day 7, namely aggregometry responses (to collagen, ADP, and calcium ionophore A23187), platelet factor 4 release, lactate dehydrogenase extracellular activity and pH. On day 7 additional aggregometry tests were carried out with pairs of activators (collagen + ADP, collagen + A23187, collagen + epinephrine, and collagen + arachidonic acid). The 8 concentrates judged as being inferior in quality by the optical apparatus also, with 1 exception, showed inferior quality as assessed from aggregometry responses and/or biochemical analyses. |
| Databáze: | OpenAIRE |
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