Toxicity Evaluation of a New Zn-Doped CuO Nanocomposite With Highly Effective Antibacterial Properties
| Autor: | Elisa Moschini, Umberto Fascio, Patrizia Bonfanti, Ilana Perelshtein, Anat Lipovsky, Aharon Gedanken, Renato Bacchetta, Anita Colombo, Luca Del Giacco, Paride Mantecca, Giuseppe Chirico |
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| Přispěvatelé: | Mantecca, P, Moschini, E, Bonfanti, P, Fascio, U, Perelshtein, I, Lipovsky, A, Chirico, G, Bacchetta, R, Del Giacco, L, Colombo, A, Gedanken, A |
| Rok vydání: | 2015 |
| Předmět: |
Copper oxide
Xenopus laevi Embryonic Development chemistry.chemical_element Nanotechnology Metal oxide nanoparticles Zinc Toxicology Nanocomposites chemistry.chemical_compound medicine Animals Nanocomposite metal oxide nanoparticle Anti-Bacterial Agents Antibacterial Oxidative Stress chemistry Mechanism of action Nanotoxicology Bioaccumulation Toxicity nanotoxicology medicine.symptom Reactive Oxygen Species Copper Nuclear chemistry |
| Zdroj: | Toxicological Sciences. 146:16-30 |
| ISSN: | 1096-0929 1096-6080 |
| DOI: | 10.1093/toxsci/kfv067 |
| Popis: | The increased resistances to conventional antibiotics determine a strong need for new antibacterials, and specific syntheses at the nanoscale promise to be helpful in this field. A novel Zinc-doped Copper oxide nanocomposite (nZn-CuO) has been recently sonochemically synthesized and successfully tested also against multi-drug resistant bacteria. After synthesis and characterization of the physicochemical properties, the new nZn-CuO is here evaluated by the Frog Embyo Teratogenesis Assay-Xenopus test for its toxicological potential and this compared with that of nCuO and nZnO synthesized under the same conditions. No lethal effects are observed, while malformations and growth retardation slightly increase after nZn-CuO exposure. Nevertheless, these effects are smaller than those of nZnO. NP uptake by embryo tissues increase significantly with increasing NP concentrations, while no significant accumulation and adverse effects are seen after exposure to soluble Cu(2+) and Zn(2+) at the concentrations dissolved from the NPs. Key oxidative response genes are upregulated by nZn-CuO, as well as by nCuO and nZnO, suggesting the common mechanism of action. Considering the enhanced biocidal activity shown by the nanocomposite, together with the results presented in this study, we can affirm that the doping of the metal oxide nanoparticles should be considered a useful tool to engineer a safer nano-antibacterial. |
| Databáze: | OpenAIRE |
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