A Simple and Fast Battery Test for Phenotypic Characterization of Mice
| Autor: | Danilo Wadt, Cezar Guizzo, Dennis Albert Zanatto, Ana Tada Fonseca Brasil Antiorio, Jilma Alemán-Laporte, Mariana de Souza Aranha Garcia-Gomes, Guilherme Andrade Marson, Pedro Kenzo Yamamoto, Maria Martha Bernardi, Claudia Madalena Cabrera Mori, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro |
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| Rok vydání: | 2020 |
| Předmět: |
Battery (electricity)
Strategy and Management Mechanical Engineering Central nervous system Sensorimotor system Metals and Alloys ANIMAIS GENETICAMENTE MODIFICADOS Sensory system Computational biology Biology Phenotype Industrial and Manufacturing Engineering Genetically modified organism Autonomic nervous system medicine.anatomical_structure Inbred strain Methods Article medicine |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Bio Protoc |
| ISSN: | 2331-8325 |
| Popis: | Despite the great number of test batteries already known to assess the behavior of genetically modified and inbred strains of mice, only a few of them focus on basic neurological parameters. The purpose of the battery test proposed is to settle a specific methodology to characterize the phenotype of neurological disease models in mutant or genetically modified mice. This methodology is simple and efficient in order to analyze several parameters, including general activity, sensory nervous system, sensorimotor system, central nervous system and autonomous nervous system. This can aid the choice of specific additional tests as well as the determination of an interrelationship among phenotypic alterations observed. Although being efficient for a first analysis of a mouse model, interpretation of the results must be carefully made because phenotype manifestation may vary due to many parameters, including mouse strain, environmental and housing condition, animal-experimenter interaction, sample size and tests order. It is important to consider as a critical point if handling procedures are aversive. The results acquired with the analysis of 18 parameters together provide preliminary data to characterize mouse phenotype and helps selecting more specific tests. |
| Databáze: | OpenAIRE |
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