New twists on H2A.Z: a histone variant with a controversial structural and functional past
| Autor: | Juan Ausió, Anita A. Thambirajah, Deanna Dryhurst |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Models
Molecular Saccharomyces cerevisiae Proteins Protein Conformation Molecular Sequence Data Saccharomyces cerevisiae Computational biology Biology Models Biological Biochemistry Histones Structure-Activity Relationship Protein structure Heterochromatin Animals Humans Immunoprecipitation Amino Acid Sequence Molecular Biology Cell Nucleus Functional specification Genetics Cell Biology Chromatin Protein Structure Tertiary Histone biology.protein Dimerization Histone variants Protein Binding |
| Zdroj: | Biochemistry and Cell Biology. 82:490-497 |
| ISSN: | 1208-6002 0829-8211 |
| DOI: | 10.1139/o04-043 |
| Popis: | Integration of histone variants into chromatin organization allows for functional specification of chromatin regions. Recent functional analyses of H2A.Z have ascribed to it a multiplicity of complex and often opposing roles in developmental and homeostatic regulation. However, although the manner in which this essential histone variant is able to mediate its effects is not entirely well understood, current work has sought to investigate its mode of action. It is becoming increasingly clear that H2A.Z does not necessarily act independently, but rather, in conjunction with trans-acting factors to elicit chromatin changes. The nature of these structural changes has remained somewhat controversial but nevertheless exemplifies the seemingly multifaceted nature of H2A.Z.Key words: histone H2A.Z, chromatin structure, transcription, heterochromatin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|