Nano-Engineered Environment for Nerve Regeneration: Scaffolds, Functional Molecules and Stem Cells
| Autor: | Liumin He, Kwok-Fai So, Wei Xue, Wutian Wu, Yongnu Zhang, Seeram Ramakrishna, Lingling Tian, Yuqiao Sun |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nervous system Medicine (miscellaneous) Biocompatible Materials Biology 03 medical and health sciences 0302 clinical medicine Functional importance Tissue engineering medicine Animals Humans Nanotechnology Tissue Engineering Tissue Scaffolds Biological phenomenon Stem Cells Regeneration (biology) General Medicine Biocompatible material Nerve Regeneration 030104 developmental biology medicine.anatomical_structure Local environment 030211 gastroenterology & hepatology Stem cell Neuroscience |
| Zdroj: | Current Stem Cell Research & Therapy. 11:605-617 |
| ISSN: | 1574-888X |
| DOI: | 10.2174/1574888x10666151001114735 |
| Popis: | One of the most complex systems in the human body is the nervous system, which is divided into the central and peripheral nervous systems. The regeneration of the CNS is a complex and challenging biological phenomenon hindered by the low regenerative capacity of neurons and the prohibition factors in response to nerve injuries. To date, no effective approach can achieve complete recovery and fully restore the functions of the nervous system once it has been damaged. Developments in neuroscience have identified properties of the local environment with a critical role in nerve regeneration. Advances in biomaterials and biomedical engineering have explored new approaches of constructing permissive environments for nerve regeneration, thereby enabling optimism with regard to nerve-injury treatment. This article reviews recent progress in nanoengineered environments for aiding nerveinjury repair and regeneration, including nanofibrous scaffolds, functional molecules, and stem cells. |
| Databáze: | OpenAIRE |
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