The novel role of mast cells in the microenvironment of acute myocardial infarction
| Autor: | Jeong Gwan Cho, Jeong Sook Kim, Jin Sook Kwon, Yong Sook Kim, Myung Ho Jeong, Seo Yeon Jeong, Jong Chun Park, Youngkeun Ahn, Ae Shin Cho, Moon Hwa Hong, Jung Chaee Kang, Hyang Hee Cho |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Angiogenesis Blotting Western Myocardial Infarction Apoptosis Tryptase Cytoplasmic Granules Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals Humans Mast Cells Myocardial infarction Molecular Biology Protein kinase B Cells Cultured Tube formation biology Reverse Transcriptase Polymerase Chain Reaction business.industry Myocardium Hemodynamics medicine.disease Mast cell Cell Hypoxia Rats medicine.anatomical_structure chemistry biology.protein Cardiology Cardiology and Cardiovascular Medicine business Histamine |
| Zdroj: | Journal of Molecular and Cellular Cardiology. 50:814-825 |
| ISSN: | 0022-2828 |
| DOI: | 10.1016/j.yjmcc.2011.01.019 |
| Popis: | Mast cells are multifunctional cells containing various mediators, such as cytokines, tryptase, and histamine, and they have been identified in infarct myocardium. Here, we elucidated the roles of mast cells in a myocardial infarction (MI) rat model. We studied the physiological and functional roles of mast cell granules (MCGs), isolated from rat peritoneal fluid, on endothelial cells, neonatal cardiomyocytes, and infarct heart (1-hour occlusion of left coronary artery followed by reperfusion). The number of mast cells had two peak time points of appearance in the infarct region at 1day and 21days after MI induction in rats (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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