New Pyrrolobenzoxazine Sesquiterpenoid Derivatives from the Fungus Talaromyces trachyspermus
| Autor: | Supattra Poeaim, Jantana Yahuafai, Boonyanoot Chaiyosang, Kasem Soytong, Pongpun Siripong, Mayamor Soytong, Somdej Kanokmedhakul, Siriporn Jungsuttiwong, Sarinya Hadsadee, Kwanjai Kanokmedhakul |
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| Rok vydání: | 2021 |
| Předmět: |
Circular dichroism
Stereochemistry Talaromyces Bacillus cereus Pharmaceutical Science Bacillus subtilis medicine.disease_cause 01 natural sciences Analytical Chemistry Drug Discovery medicine Humans Escherichia coli Pharmacology Trichocomaceae biology 010405 organic chemistry Chemistry Organic Chemistry Hep G2 Cells biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Molecular Medicine Antibacterial activity Sesquiterpenes Bacteria |
| Zdroj: | Planta Medica. 87:600-610 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/a-1392-1038 |
| Popis: | Three new pyrrolobenzoxazine sesquiterpenoids, talatrachyoxazines A – C (1 – 3), together with fourteen known compounds (4 – 17), were isolated from the fungus Talaromyces trachyspermus EU23. Their structures were identified by spectroscopic evidence and mass spectrometry. The absolute configurations of 1 – 3 were determined by NOESY data and comparison of their calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 showed cytotoxic activity against HelaS3, KB, HT-29, MCF-7, and HepG2 cell lines with IC50 values of 7, 11, 10, 12, and 10 µM, respectively. Compounds 1 and 14 showed weak antibacterial activity against the gram-positive bacteria Bacillus cereus and Bacillus subtilis, while 1 – 3 and 14 showed weak antibacterial activity against the gram-negative bacterium Pseudomonas aeruginosa. In addition, compound 1 showed weak antibacterial activity against Escherichia coli. |
| Databáze: | OpenAIRE |
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