Dilevalol compared with propranolol and placebo for systemic hypertension
| Autor: | J.David Wallin, Judith Cubbon, Glen D. Bedsole, Eric L. Michelson, Marcia P. Poland, William H. Frishman, Michael Davidov, Jeffrey Gorwit, James A. Schoenberger |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Bradycardia medicine.medical_specialty Supine position Diastole Vasodilation Propranolol Placebo Supination Drug Administration Schedule Random Allocation Double-Blind Method Heart Rate Internal medicine medicine Humans Multicenter Studies as Topic Labetalol Aged business.industry Antagonist Middle Aged Blood pressure Anesthesia Hypertension Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American Journal of Cardiology. 63:I45-I49 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(89)90128-8 |
| Popis: | Dilevalol is a new antihypertensive agent that is both a vasodilator, through its β2-agonist action, and a nonselective β antagonist. Two multicenter, double-blind studies were performed: study 1 compared dilevalol administered once-daily with either dilevalol or propranolol every 12 hours; study 2 compared dilevalol administered once daily with placeco. Both studies had a placebo run-in period to establish that the baseline supine diastolic blood pressures were consistent in the mild to moderate severity range (95 to 115 mm Hg) at 2 consecutive visits for study 1 and in the mild severity range (95 to 105 mm Hg) in study 2. Patients then were randomized to the double-blind titration phase, during which doses were titrated over a 9-week period to achieve a supine diastolic blood pressure of < 90 mm Hg and a decrease from baseline of ≥10 mm Hg. Patients were then maintained on a fixed dose for 2 months (study 1) or for 1 month (study 2). Dilevalol given once daily was as effective in reducing supine diastolic blood pressure as dilevalol every 12 hours and propranolol every 12 hours (study 1) and was superior to placebo (p < 0.001) (study 2). In both studies, dilevalol given once daily was effective and well tolerated. The side-effect profile of dilevalol was similar to that of placebo and different from that of propranolol. Treatment with dilevalol resulted in significantly less fatigue (p < 0.05), bradycardia (< 50 beats/minute) and mental depression than with propranolol, but significantly (p < 0.05) more diarrhea/loose stools. Dilevalol's effectiveness and favorable side-effect profile should make it a useful addition to the pharmacopoeia of antihypertensive agents. |
| Databáze: | OpenAIRE |
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