Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
| Autor: | Wojciech Młynarski, Miron Chumiecki, Pawel Bernatowicz, Barbara Głowińska-Olszewska, Wojciech Fendler, Artur Bossowski, Agnieszka Szadkowska, Agnieszka Szypowska, Oksana Kowalczuk, Włodzimierz Łuczyński, Anna Ramatowska, Przemysława Jarosz-Chobot, Anna Noczyńska, Joanna Chrzanowska, Agnieszka Brandt, Małgorzata Myśliwiec |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Type 1 diabetes lcsh:RC648-665 endocrine system diseases Article Subject Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism INSIG2 nutritional and metabolic diseases Overweight medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology FTO gene Obesity Endocrinology Internal medicine Metabolic control analysis medicine medicine.symptom Allele business Body mass index Research Article |
| Zdroj: | International Journal of Endocrinology International Journal of Endocrinology, Vol 2014 (2014) |
| ISSN: | 1687-8337 |
| DOI: | 10.1155/2014/630712 |
| Popis: | The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants ofFTO,MC4R,INSIG2,FASN,NPC1,PTER,SIRT1,MAF,IRT1, andCD36.Results.Variants ofFTOshowed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P=0.0003), poor metabolic control (P=0.0001), and carriage of the A allele of theFTOrs9939609 gene (P=0.02).Conclusion.Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of theFTOgene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|