Relationship between Blood Flow Kinetics and Severity of Alzheimer’s Disease: Assessment of Severity Using a Questionnaire-Type Examination, Alzheimer’s Disease Assessment Scale, Cognitive Sub-Scale (ADAScog)
| Autor: | Kazuhiko Hokoishi, Takuo Yasuoka, Manabu Ikeda, Naruhiko Maki, Akihiko Nebu, Kazue Shigenobu, Kenjiro Komori, Ryuji Fukuhara, Hirotaka Tanabe |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Severity of Illness Index Central nervous system disease Degenerative disease Alzheimer Disease Surveys and Questionnaires Internal medicine medicine Humans Aged Aged 80 and over Psychiatric Status Rating Scales Tomography Emission-Computed Single-Photon Temporal cortex Analysis of Variance Brain Cognition Blood flow Middle Aged medicine.disease Surgery Psychiatry and Mental health nervous system Cerebral blood flow Cerebrovascular Circulation Cardiology Female Disease assessment Geriatrics and Gerontology Alzheimer's disease Psychology Blood Flow Velocity |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 12:318-325 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000051277 |
| Popis: | We assessed hemokinetics associated with changes in Alzheimer’s disease (AD) severity in 90 AD patients by researching the relationship between AD Assessment Scale, cognitive sub-scale (ADAScog) scores and regional cerebral blood flow (rCBF). In the present study, we employed the questionnaire-type ADAScog examination to accurately assess the severity of AD. Between five groups classified on the basis of ADAScog score, significant differences were observed in parietal, lateral temporal and superior frontal rCBF. In addition, in parietal and lateral temporal regions, significant correlations were also observed between ADAScog score and rCBF. In superior frontal rCBF, significant differences were noted only between group 5 (≥40 ADAScog points) and each of the other groups; there was no significant correlation between rCBF and ADAScog score. Thus, we propose the following mechanism for blood flow kinetics associated with changed severity: In an early stage of AD, blood flow in the medial temporal cortex is impaired, and gradually involves the temporoparietal regions. While the medial temporal impairment of blood flow reaches a plateau, temporoparietal blood flow continues to be impaired well into a severe stage, at which point blood flow impairment in the frontal region is initiated. |
| Databáze: | OpenAIRE |
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