Acute carotid occlusion alters the activation flow coupling response to forepaw stimulation in a rat model
| Autor: | B M, Ances, J H, Greenberg, J A, Detre, W D, Dietrich |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty Time Factors Haemodynamic response Hemodynamics Arterial Occlusive Diseases Vascular occlusion Rats Sprague-Dawley Internal medicine Occlusion Forelimb Medicine Animals Advanced and Specialized Nursing business.industry Anatomy Somatosensory Cortex Laser Doppler velocimetry Arterial occlusion Electric Stimulation Rats Cerebral blood flow Carotid artery occlusion Cerebrovascular Circulation Acute Disease Cardiology Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 31(4) |
| ISSN: | 0039-2499 |
| Popis: | Background and Purpose —To determine whether the hemodynamic response to functional stimulation is sensitive to proximal arterial occlusion, we measured the activation flow coupling response in a rat model of acute reversible vascular occlusion. Methods —In α-chloralose–anesthetized rats (n=18), laser Doppler measurements were made through a thinned skull over the somatosensory cortex in response to electrical forepaw stimulation. Signal-averaged responses to 4 and 8 seconds of electrical forepaw stimulation were obtained before, during, and shortly after acute unilateral or bilateral carotid occlusion produced with the use of a surgically placed snare. Results —Baseline cerebral blood flow was significantly decreased over the forepaw region of the somatosensory cortex after both occlusion of the carotid contralateral to the stimulated forepaw and bilateral occlusion compared with preocclusion ( P P P P Conclusions —These findings suggest that temporal characteristics of functional activation responses are sensitive to alterations in the proximal arterial supply and, conversely, that functional activation studies must be interpreted with consideration of proximal arterial disease. |
| Databáze: | OpenAIRE |
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