Cardiovascular risk reduction with icosapent ethyl
| Autor: | Parth N Patel, Siddharth M Patel, Deepak L. Bhatt |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
MEDLINE 030204 cardiovascular system & hematology Triglycerides blood law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Risk Factors law Internal medicine medicine Humans 030212 general & internal medicine Triglycerides Randomized Controlled Trials as Topic Lipoprotein cholesterol Hypertriglyceridemia Lipid Regulating Agents Atherosclerotic cardiovascular disease business.industry Atherosclerosis Eicosapentaenoic Acid Cardiovascular Diseases Cardiology lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Risk Reduction Behavior |
| Zdroj: | Current Opinion in Cardiology. 34:721-727 |
| ISSN: | 0268-4705 |
| DOI: | 10.1097/hco.0000000000000678 |
| Popis: | Residual risk for atherosclerotic cardiovascular disease (ASCVD) persists even among patients with optimal low-density lipoprotein cholesterol (LDL-C) levels. Randomized trials attempting to modulate other lipids beyond LDL-C have failed to demonstrate significant reductions in ischemic events.Mounting evidence suggests that triglyceride elevation is an independent risk factor for ASCVD. Though trials of triglyceride-lowering therapy in the statin era have failed to provide protection from ASCVD events, subgroup analyses have revealed that those with the highest triglycerides at time of enrollment appeared to receive the greatest clinical benefit. REDUCE-IT was a trial that enrolled patients with high triglycerides despite having goal LDL-C levels on statin therapy. Treatment with icosapent ethyl, a highly purified omega-3 fatty acid (OM3FA), eicosapentaenoic acid ethyl ester, provided a 25% relative risk reduction for the primary composite cardiovascular endpoint (hazard ratio 0.75, 95% CI 0.68--0.83; P = 0.00000001), as well as a 30% relative risk reduction in total ischemic events (P = 0.00000000036).Icosapent ethyl was rigorously shown to decrease residual risk for cardiovascular events, though the benefits seen were likely because of mechanisms beyond mere triglyceride lowering. Clinical application of icosapent ethyl in this cohort of patients with residual risk is urgently needed. |
| Databáze: | OpenAIRE |
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