Pancreatic tumors show high levels of hypoxia
| Autor: | Augusto J. Bastidas, Albert C. Koong, Vivek K. Mehta, J. Martin Brown, Mark A. Vierra, David J. Terris, Q.T. Le, George A. Fisher |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Pancreatic disease Partial Pressure medicine Humans Radiology Nuclear Medicine and imaging Pancreas Aged Radiation Tumor hypoxia business.industry Oxygenation Tumor Oxygenation Hypoxia (medical) Middle Aged medicine.disease Cell Hypoxia Oxygen Pancreatic Neoplasms medicine.anatomical_structure Oncology Adenocarcinoma Female medicine.symptom business Chemoradiotherapy |
| Zdroj: | International journal of radiation oncology, biology, physics. 48(4) |
| ISSN: | 0360-3016 |
| Popis: | Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|