Pancreatic beta cells persistently infected with coxsackievirus B4 are targets of NK cell-mediated cytolytic activity
| Autor: | Ilka Engelmann, Jacques Trauet, Famara Sane, Didier Hober, Delphine Lobert, Akadiri Yessoufou, Kabirou Moutairou, Antoine Bertin, C. Hober, Enagnon Kazali Alidjinou, Magloire Pandoua Nekoua |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Viral protein Viral pathogenesis Cell Coxsackievirus Infections Human leukocyte antigen Biology Coxsackievirus medicine.disease_cause Peripheral blood mononuclear cell Cell Line Cellular and Molecular Neuroscience Insulin-Secreting Cells medicine Humans Viability assay Molecular Biology Pharmacology Immunity Cellular Cell Biology Middle Aged biology.organism_classification Enterovirus B Human Killer Cells Natural Cytolysis Diabetes Mellitus Type 1 medicine.anatomical_structure Immunology Molecular Medicine |
| Zdroj: | Cellular and Molecular Life Sciences. 77:179-194 |
| ISSN: | 1420-9071 1420-682X |
| Popis: | It has been suggested that the persistence of coxsackieviruses-B (CV-B) in pancreatic beta cells plays a role in the pathogenesis of type 1 diabetes (T1D). Yet, immunological effectors, especially natural killer (NK) cells, are supposed to clear virus-infected cells. Therefore, an evaluation of the response of NK cells to pancreatic beta cells persistently infected with CV-B4 was conducted. A persistent CV-B4 infection was established in 1.1B4 pancreatic beta cells. Infectious particles were found in supernatants throughout the culture period. The proportion of cells containing viral protein VP1 was low ( |
| Databáze: | OpenAIRE |
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