Anteromedial GPi deep brain stimulation in Tourette syndrome: The first case series from Iran
| Autor: | Arash Fattahi, Amirhassan Habibi, Morteza Taheri, Alireza Azimi, Gholam Ali Shahidi, Mahdi Safdarian, Sadra Rohani, Mansour Parvaresh, Mohammad Rohani |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Pediatrics medicine.medical_specialty Deep brain stimulation Tics Deep Brain Stimulation medicine.medical_treatment Iran Globus Pallidus Severity of Illness Index Tourette syndrome 03 medical and health sciences 0302 clinical medicine Quality of life Refractory Humans Medicine Phonic Tic business.industry General Medicine medicine.disease nervous system diseases Diagnostic and Statistical Manual of Mental Disorders Treatment Outcome 030104 developmental biology Neuropsychiatric disorder Globus pallidus nervous system Quality of Life Female Surgery Neurology (clinical) business 030217 neurology & neurosurgery Tourette Syndrome |
| Zdroj: | Clinical Neurology and Neurosurgery. 172:116-119 |
| ISSN: | 0303-8467 |
| DOI: | 10.1016/j.clineuro.2018.06.045 |
| Popis: | Objectives Tourette syndrome (TS) is a neuropsychiatric disorder characterized by childhood onset motor and phonic tics. In refractory cases, deep brain stimulation (DBS) with different targets including anteromedial Globus pallidus (AM-GPi) looks promising. Patients and Methods Patients with TS diagnosed according to DSM-IV TR criteria with severe medication-recalcitrant disease referred to our DBS clinic, were recruited for this study. They underwent bilateral AM-GPi DBS with Model 3389, Medtronic electrodes. Patients were assessed using Yale Global Tic Severity Scale (YGTSS) and Gilles de la Touretts syndrome-quality of life (GTS-QOL) questionnaire before and one year after DBS. Results Six patients (four men and two women) with severe medication-recalcitrant TS, mean age of 26.33 ± 7.25 years fulfilled the follow up visits. All patients revealed significant improvement in tics severity one year after surgery. Based on YGTSS, total tic severity score decreased from 75.66 ± 16.54 to 28.33 ± 13.95, P-value:0.005. Quality of life improved significantly after DBS (26.66 ± 20.65 before and 70.00 ± 17.88 one year after surgery, P-value:0.02). Conclusions Results of our study in accordance to previous ones suggest AM-GPi DBS as an effective and well-tolerated therapeutic modality for patients with medication refractory TS. |
| Databáze: | OpenAIRE |
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