Effects of inhibiting astrocytes and BET/BRD4 chromatin reader on spatial memory and synaptic proteins in rats with Alzheimer's disease
| Autor: | Rastin Nikkar, Aghil Esmaeili-bandboni, Mahshid Badrikoohi, Parvin Babaei |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Amyloid beta-Peptides Tumor Necrosis Factor-alpha Synaptophysin Nuclear Proteins Biochemistry Chromatin Epigenesis Genetic Rats Cellular and Molecular Neuroscience Alzheimer Disease Astrocytes Animals Dimethyl Sulfoxide Neurology (clinical) Rats Wistar Cyclic AMP Response Element-Binding Protein Spatial Memory |
| Zdroj: | Metabolic brain diseaseReferences. 37(4) |
| ISSN: | 1573-7365 |
| Popis: | Communication between astrocytes and neurons has a profound effect on the pathophysiology of Alzheimer's disease (AD). Astrocytes regulate homeostasis and increase synaptic plasticity in physiological situations, however, they become activated during the progression of AD. Whether or not these reactions are supportive or detrimental for the central nervous system have not been understood yet. Considering epigenetic regulation of neuroinflammatory genes by chromatin readers, particularly bromodomain and extraterminal domain (BET) family, here we examined the effect of chronic co-inhibition of astrocytes metabolism (with fluorocitrate) and also BRD4 (with JQ1) on cognition deficit at early stages of AD. Forty adult male Wistar rats underwent stereotaxic cannulation for inducing AD by intrahippocampal injection of Aβ |
| Databáze: | OpenAIRE |
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