Primary extragastrointestinal stromal tumors: a clinicopathological and immunohistochemical study - a tertiary care center experience
| Autor: | P D Prasad, Chowhan Ak, Mandyam Kumaraswamy Reddy, Phaneendra Bv, A Jena, Rashmi Patnayak, N Rukamangadha, Sriram Parthasarathy |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Radiography Abdominal Pathology medicine.medical_specialty CD34 Antigens CD34 Diagnosis Differential Tertiary Care Centers Young Adult Abdomen Medicine Humans Mesentery Radionuclide Imaging Peritoneal Neoplasms Aged Neoplasms Connective Tissue biology business.industry CD117 Sarcoma Middle Aged Immunohistochemistry Actins Proto-Oncogene Proteins c-kit medicine.anatomical_structure Oncology Connective tissue metabolism biology.protein Desmin Female Differential diagnosis business Pancreas |
| Zdroj: | Indian journal of cancer. 50(1) |
| ISSN: | 1998-4774 |
| Popis: | Background: Extra gastrointestinal stromal tumors (EGIST) are uncommon compared to their gastrointestinal counterparts. EGISTs involve omentum, mesentery, retroperitoneum, pancreas, and pelvis. Materials and Methods: Ten EGISTs were analyzed in this study from January 1995 to November 2011. They were analyzed with respect to clinical features, imageological, histopathological, and immunohistochemical findings. The immunohistochemical stains used were Smooth muscle actin (SMA), Desmin, S-100 protein, CD34 and CD-117. Results: There was slight female preponderance with wide age range. Four of the tumors were in retroperitoneum, three in mesentery, and two in omentum and one in pelvis. Histopathologically majority were spindle cell tumors. Immunohistochemically CD117 was consistently positive followed by CD34. Smooth muscle actin was positive in eight cases, S-100 protein and desmin were positive in two cases each. Conclusion: EGISTs are rare and should be considered in the differential diagnosis of the mesenchymal tumors and immunohistochemistry helps to confirm the diagnosis. Further study with better follow-up is desired to characterize these uncommon tumors. |
| Databáze: | OpenAIRE |
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