Determination of ethinylestradiol and norgestrel in water using solid-phase microextraction
| Autor: | Yerlan Adilbekov, Mereke Alimzhanova, Svetlana Batyrbekova, Yenglik T. Nurzhanova |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Chemistry 010401 analytical chemistry General Medicine 010501 environmental sciences mass-spectrometry Mass spectrometry Solid-phase microextraction 01 natural sciences Water sample 0104 chemical sciences lcsh:Chemistry lcsh:QD1-999 gas-chromatography solid-phase microextraction water sample ethinylestradiol Gas chromatography 0105 earth and related environmental sciences |
| Zdroj: | Chemical Bulletin of Kazakh National University, Iss 3-4, Pp 52-62 (2016) |
| ISSN: | 2312-7554 1563-0331 |
| Popis: | Endocrine disrupting compounds (EDCs) are exogenous substances that alter some function of the endocrine system and have adverse health effects on intact organisms, their off spring or (sub)populations. EDCs mimic or block the action of natural hormones, and hence biological functions in living organisms, thus leading to impaired reproduction, growth and development. The article focuses on the development of analytical method based on solid-phase microextraction and gas chromatography – mass spectrometry for detection of steroid hormones ethinylestradiol and norgestrel in water samples. In this work, studies were carried out on model water samples spiked with a mixture of ethinylestradiol and norgestrel. The following parameters of headspace solid-phase microextraction were optimized as a result of experiments: extraction temperature 80°C, extraction time 20 min, NaCl additive – 1.5 g, fiber coating – 65 µm PDMS/DVB. |
| Databáze: | OpenAIRE |
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