Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis

Autor: Cesar A. Speck-Hernandez, Adriana Rojas-Villarraga, Rubén D. Mantilla, Juan-Manuel Anaya, Gladis Montoya-Ortiz, Carolina Barragán-Martínez
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Aldehyde-protein adducts
Non-Clinical Medicine
Epidemiology
Vinyl-chloride exposure
Population Dynamics
Occupational-exposure
Review Literature as Topic
Represión epigenética
Bioinformatics
Enfermeras anestesistas
Evolución & genética
Activación de células T
Lupus-erythematosus
Risk Factors
Medicine
Organic Chemicals
Multidisciplinary
Chemical Reactions
Risk factor (computing)
Chemistry
Primary biliary cirrhosis
Tricloroeteno
Meta-analysis
Autoinmunidad mediada
Exposición al cloruro de vinilo
Research Article
Metapopulation Dynamics
Pollutants
Clinical Research Design
Science
Scleroderma disease
Environmental Epidemiology
Autoimmune Diseases
Environmental-factors
Exposicion ocupacional
Enfermedades autoinmunes
Multiple-sclerosis
Humans
Environmental Chemistry
Cirrosis biliar primaria
Aductos de proteína de aldehído
Biology
Organic Reactions
Health Care Policy
Population Biology
business.industry
Factores medioambientales
Computational Biology
Lupus eritematoso
Genética
Nurse anesthetists
Trichloroethene-mediated autoimmunity
Esclerosis múltiple
Case-Control Studies
Immunology
Solvents
Clinical Immunology
Meta-Analyses
Health Statistics
business
T-cell-activation
Zdroj: PLoS ONE, Vol 7, Iss 12, p e51506 (2012)
PLoS ONE
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
ISSN: 1932-6203
Popis: BackgroundGenetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs.Methods and findingsThe systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-valueConclusionExposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.
Databáze: OpenAIRE
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