The prognostic value of immature granulocyte in patients with acute pancreatitis
| Autor: | Hüseyin Narcı, Serkan Karakulak, Cüneyt Ayrık, Semra Erdoğan, Enver Üçbilek |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Turkey Disease Sensitivity and Specificity Severity of Illness Index Gastroenterology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans In patient Hospital Mortality Retrospective Studies Receiver operating characteristic business.industry Immature Granulocyte Curve analysis 030208 emergency & critical care medicine General Medicine Emergency department Middle Aged Prognosis medicine.disease Pancreatitis Emergency Medicine Acute pancreatitis Female Emergency Service Hospital business Biomarkers Granulocytes |
| Zdroj: | The American Journal of Emergency Medicine. |
| ISSN: | 0735-6757 |
| DOI: | 10.1016/j.ajem.2020.03.028 |
| Popis: | Background Acute pancreatitis is the inflammation of the pancreas. It can range from mild forms to life-threatening severe cases. There is not yet a marker that can detect severe cases in the early period. Early diagnosis and treatment of this disease has critical importance for prognosis. In this study, we aimed to investigate the percentage of immature granulocyte (IG %) in patients with acute pancreatitis in order to predict the severity of the disease and in-hospital mortality. Method This study was carried out retrospectively in academic emergency department (ED), faculty of medicine between 01.01.2017 and 30.06.2019. The patients were divided into three groups as mild, moderate and severe. In addition, the patients were divided into two groups: those discharged from the hospital and those who died in the hospital. IG % and other laboratory parameters of the patients were recorded in the study form. The primary outcome for this study is the value of IG% in predicting severity in AP patients. A receiver operating characteristic (ROC) curve analysis was performed. Results A total of 218 patients (107 male) were included in the study. The mean age of the patients was 56.9 ± 18.3 years. It was found that IG% levels were higher in patients with severe pancreatitis (p = .018). In the ROC analysis that was done to determine the severity of the disease, the cut-off value of IG% was found as >1.1. As such case, specificity was %38.89, sensitivity was 95.00%, positive predictive value (PPV) was 41.18% and negative predictive value (NPV) was found as 94.53% (Area Under Curve (AUC) = 0.698). In ROC analysis that was performed to determine in-hospital mortality, the cut-off value of IG level was found as >1.8, sensitivity was 50.00%, specificity was 97.12%, PPV was 45.45% and NPV was found as 97.58% (AUC = 0.708). Conclusions This study shows that higher IG% levels may correlate with higher disease severity and in-hospital mortality in patients with acute pancreatitis. |
| Databáze: | OpenAIRE |
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