Cardiorespiratory Fitness Predicted by Fibrinogen and Leptin Concentrations in Children with Obesity and Risk for Diabetes: A Cross-Sectional Study and a ROC Curve Analysis

Autor: Kyriaki Tsiroukidou, Elpis Hatziagorou, John Tsanakas, Anastasios Vamvakis, Bessie E. Spiliotis, Kalliopi Kontouli, Maria G. Grammatikopoulou, Christos Tzimos
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Blood Glucose
Leptin
Male
Overweight
0302 clinical medicine
Risk Factors
insulin resistance
Insulin
030212 general & internal medicine
VO2max
Child
adiposity
Nutrition and Dietetics
exercise
high-sensitive CRP
VO2 max
nutrition
Cardiorespiratory Fitness
Female
Adiponectin
medicine.symptom
lcsh:Nutrition. Foods and food supply
cardiopulmonary test
medicine.medical_specialty
Adolescent
Adipokine
lcsh:TX341-641
030209 endocrinology & metabolism
Article
03 medical and health sciences
Insulin resistance
Oxygen Consumption
CPET
Internal medicine
medicine
Diabetes Mellitus
Humans
overweight
Obesity
childhood
metabolic health
obese
business.industry
Fibrinogen
Cardiorespiratory fitness
medicine.disease
Endocrinology
Cross-Sectional Studies
ROC Curve
Case-Control Studies
Exercise Test
business
Food Science
Zdroj: Nutrients
Volume 13
Issue 2
Nutrients, Vol 13, Iss 674, p 674 (2021)
ISSN: 2072-6643
Popis: Obesity is defined as abnormal or excessive fat accumulation that presents a risk to health. The ability to exercise is affected by adiposity, and this mechanism involves low-grade chronic inflammation and homeostatic stress produced mainly in adipocytes, which can result in abnormal adipokine secretion. To date, the gold standard for cardiorespiratory fitness assessment is considered to be the maximum oxygen uptake (VO2max). The aim of the present study was to assess the prognostic value of hematological parameters of childhood obesity, as potential predictors of cardiorespiratory fitness (VO2max), using a sample of children and adolescents with obesity and risk for diabetes. A total of 84 clinically healthy children and adolescents were recruited, of which 21 were considered lean, 22 overweight and 41 obese, with a mean age of 12.0 ± 1.9, 11.4 ± 2.0, and 11.2 ± 2.1 years old, in each weight status category, respectively. Age and sex did not differ between groups. Hematologic testing was performed after 12 h of fasting including glucose, serum lipids, insulin, hc-CRP, adiponectin, leptin and fibrinogen levels. Cardiorespiratory capacity for exercise was assessed to determine VO2max, using a cycle ergometer. The VO2max was negatively correlated with progressive strength to the BMIz (−0.656, p ≤ 0.001), hs-CRP (r = −0.341, p ≤ 0.002), glucose (r = −0.404, p ≤ 0.001) and insulin levels (r = −0.348, p ≤ 0.001), the homeostasis model assessment of insulin resistance (HOMA-IR) (r = −0.345, p ≤ 0.002), as well as to the leptin (r = −0.639, p ≤ 0.001) and fibrinogen concentrations (r = −0.520, p ≤ 0.001). The multivariate analysis revealed that only leptin and fibrinogen concentrations could predict the VO2max adjusted for the BMIz of participants. The receiver operating characteristic (ROC) curve for the diagnostic accuracy of leptin, hs-CRP and fibrinogen concentrations for the prediction of VO2max revealed a good diagnostic ability for all parameters, with leptin being the most promising one (area under the curve (AUC): 99%). The results verify that in children with obesity, VO2max may be predicted from hematological parameters (leptin and fibrinogen), possibly bypassing more invasive methods.
Databáze: OpenAIRE
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