Zinc finger protein A20 regulates the development and progression of osteoarthritis by affecting the activity of NF-κB p65
| Autor: | Tao-Xia Wang, Shu-Bei Cui, Ji-Ying Yan, Kai Zhang, Zhen-Wu Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
MMP1 Immunology Down-Regulation Inflammation Osteoarthritis Toxicology Mice immune system diseases hemic and lymphatic diseases medicine Immunology and Allergy Animals Humans Cells Cultured Tumor Necrosis Factor alpha-Induced Protein 3 Pharmacology Zinc finger Chemistry Cartilage Transcription Factor RelA Zinc Fingers General Medicine medicine.disease Nf κb p65 Mice Inbred C57BL medicine.anatomical_structure Cancer research Disease Progression Female medicine.symptom |
| Zdroj: | Immunopharmacology and immunotoxicology. 43(6) |
| ISSN: | 1532-2513 |
| Popis: | To investigate the role of Zinc finger protein A20 in osteoarthritis (OA) by regulating NF-κB p65.A20 was reduced in OA cartilage samples, and its overexpression, by suppressing the activity of NF-κB p65, could improve IL-1β-induced chondrocyte degradation and apoptosis |
| Databáze: | OpenAIRE |
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