Sex differences in FSH-regulatory peptides in pubertal age boys and girls and effects of sex steroid treatment
| Autor: | Michael S. Racine, Pamela R. Olton, Carol M. Foster, David James Phillips, Vasantha Padmanabhan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Aging Adolescent medicine.drug_class Turner Syndrome Follicle-stimulating hormone Internal medicine Turner syndrome medicine Humans Inhibins Testosterone Child Gonadal Steroid Hormones Inhibin-beta Subunits Sex Characteristics biology Estradiol Rehabilitation Puberty Obstetrics and Gynecology medicine.disease Activins Sexual dimorphism Endocrinology Reproductive Medicine Sex steroid biology.protein Female Gonadotropin Follicle Stimulating Hormone hormones hormone substitutes and hormone antagonists Follistatin Sex characteristics |
| Zdroj: | Human reproduction (Oxford, England). 19(7) |
| ISSN: | 0268-1161 |
| Popis: | BACKGROUND: FSH concentrations are higher in girls than in boys before puberty. We hypothesized that steroid-mediated changes in FSH-regulatory proteins underlie the sex differences in FSH secretion and pubertal timing. METHODS: FSH-regulatory proteins, LH, FSH and sex steroids were measured in five boys, 10 girls, and five girls with Turner syndrome before and during sex steroid treatment (girls, 0.05 mg/day estradiol; boys, 5 mg/day testosterone) for up to 4 weeks. Blood was obtained every 15 min from 20.00 to 08.00 h before and during sex steroid treatment. RESULTS: The mean FSH concentration was higher in girls than in boys (P = 0.0044). Activin-A concentrations were greater (P < 0.0001) and inhibin-B concentrations lower (P < 0.0001) in girls compared with boys. Steroid treatment (i) suppressed LH/FSH concentrations in all subjects; (ii) increased the mean activin-A concentration in all but the Turner girls (P = 0.001); and (iii) decreased inhibin-B concentrations in boys (P = 0.005) but not in girls. Total follistatin and follistatin 288 concentrations did not differ by sex. CONCLUSIONS: Sex steroids regulate circulating activin-A and inhibin-B concentrations in children. The lower inhibin-B and higher activin-A concentrations may explain the higher FSH and earlier onset of puberty in girls. |
| Databáze: | OpenAIRE |
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