Internal representation of hippocampal neuronal population spans a time-distance continuum
| Autor: | Vincent Villette, Susanne Reichinnek, Alessandro Torcini, Rosa Cossart, Caroline Haimerl, Arnaud Malvache, David Angulo-Garcia |
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| Přispěvatelé: | Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique et Modélisation (LPTM - UMR 8089), Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), Torcini, Alessandro, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Space representation
Attractor network Computer science [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Models Neurological Neural model Hippocampus Task (project management) 03 medical and health sciences Mice 0302 clinical medicine Memory Animals Time representation Episodic memory CA1 Region Hippocampal 030304 developmental biology Network model Neurons 0303 health sciences Sequence Multidisciplinary Continuum (topology) [SCCO.NEUR]Cognitive science/Neuroscience [SCCO.NEUR] Cognitive science/Neuroscience Representation (systemics) [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Biological Sciences Moment (mathematics) Nerve Net Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (15), pp.7477-7482. ⟨10.1073/pnas.1718518116⟩ Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (15), pp.7477-7482. ⟨10.1073/pnas.1718518116⟩ Proceedings of the National Academy of Sciences of the United States of America 116 (2019): 7477–7482. doi:10.1073/pnas.1718518116 info:cnr-pdr/source/autori:Haimerl C.; Angulo-Garcia D.; Villette V.; Reichinnek S.; Torcini A.; Cossart R.; Malvache A./titolo:Internal representation of hippocampal neuronal population spans a time-distance continuum/doi:10.1073%2Fpnas.1718518116/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2019/pagina_da:7477/pagina_a:7482/intervallo_pagine:7477–7482/volume:116 |
| ISSN: | 0027-8424 1091-6490 |
| Popis: | International audience; The hippocampus plays a critical role in episodic memory: the sequential representation of visited places and experienced events. This function is mirrored by hippocampal activity that self organizes into sequences of neuronal activation that integrate spatio-temporal information. What are the underlying mechanisms of such integration is still unknown. Single cell activity was recently shown to combine time and distance information; however, it remains unknown whether a degree of tuning between space and time can be defined at the network level. Here, combining daily calcium imaging of CA1 sequence dynamics in running head-fixed mice and network modeling, we show that CA1 network activity tends to represent a specific combination of space and time at any given moment, and that the degree of tuning can shift within a continuum from one day to the next. Our computational model shows that this shift in tuning can happen under the control of the external drive power. We propose that extrinsic global inputs shape the nature of spatio-temporal integration in the hippocampus at the population level depending on the task at hand, a hypothesis which may guide future experimental studies. |
| Databáze: | OpenAIRE |
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