Oxygen-generating smart hydrogels supporting chondrocytes survival in oxygen-free environments
| Autor: | Mirian Michelle Machado de Paula, Marcus A.F. Corat, Samson Afewerki, Thiago Domingues Stocco, Anderson Oliveira Lobo, Caterine Yesenia Carrasco Montesdeoca, Fernanda Roberta Marciano |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Context (language use) 02 engineering and technology Smart material 01 natural sciences Gelatin Chondrocyte Chondrocytes Colloid and Surface Chemistry food Tissue engineering 0103 physical sciences medicine Physical and Theoretical Chemistry Tissue Engineering 010304 chemical physics Chemistry Cartilage Biomaterial Hydrogels Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Oxygen medicine.anatomical_structure Self-healing hydrogels 0210 nano-technology Biotechnology Biomedical engineering |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 194:111192 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2020.111192 |
| Popis: | Cartilage is one of our body's tissues which are not repaired automatically by itself. Problems associated with cartilage are very common worldwide and are considered the leading cause of pain and disability. Smart biomaterial or "Four dimensional" (4D) biomaterials has started emerging as a suitable candidate, which are principally three dimensional (3D) materials that change their morphology or generate a response measured at space and time to physiologic stimuli. In this context, the release of oxygen through hydrogels in contact with water is considered as 4D biomaterials. The objective of this study is to develop strategies to release oxygen in a sustainable and prolonged manner through hydrogels systems to promote chondrocytes survival in oxygen-free environment. The 4D biomaterials are engineered from gelatin methacryloyl (GelMA) loaded with calcium peroxide (CPO), which have the ability to generate oxygen in a controlled and sustained manner for up to 6 days. The incorporation of CPO into the hydrogel system provided materials with enhanced mechanical and porosity properties. Furthermore, the hydrogels promoted chondrocyte survival and reduced cell death under oxygen-free conditions. |
| Databáze: | OpenAIRE |
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