Caffeine clearance in the horse

Autor:	J. S. Spano, S. H. Duran, James Schumacher, D. C. Ruffin, R. C. Wilson, Fred J. DeGraves
Rok vydání:	1994
Předmět:	Volume of distribution Male Chromatography General Veterinary Harmonic mean Horse General Medicine Body weight Immunoenzyme Techniques chemistry.chemical_compound chemistry Pharmacokinetics Caffeine Injections Intravenous Animals Female Liver function Horses Rank correlation
Zdroj:	Veterinary research communications. 18(5)
ISSN:	0165-7380
Popis:	The pharmacokinetic properties of intravenously administered caffeine were studied in 10 horses using a commercially available automated enzyme immunoassay. The harmonic mean for the distribution half-life was 5.2 min (range 1.4-18.7). The harmonic mean for the elimination half-life was 10.18 h (range 6.82-20.92). The harmonic mean of the volume of distribution was 0.32 L/kg (range 0.22-0.53). There was no correlation between the dose of caffeine/kg body weight and the elimination half-life (Spearman's coefficient of rank correlation = 0.19).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca19afd56ae72e2e306180ddf5d36e2e https://pubmed.ncbi.nlm.nih.gov/7863608 Zobrazit plný text záznamu Full text from SpringerLink