Collateral axonal projections from the A1 noradrenergic cell group to the paraventricular nucleus and bed nucleus of the stria terminalis in the rat
| Autor: | Brain A. Flumerfelt, A. W. Hrycyshyn, John M. Woulfe |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Sympathetic Nervous System Efferent Biology Synaptic Transmission Cerebral Ventricles chemistry.chemical_compound Developmental Neuroscience Dopamine medicine Animals Medulla Basal forebrain Brain Mapping Medulla Oblongata Rats Inbred Strains Anatomy Amygdala Axons Rats Phenylethanolamine Stria terminalis medicine.anatomical_structure nervous system Neurology chemistry Microscopy Fluorescence Hypothalamus Nucleus Neuroscience medicine.drug Paraventricular Hypothalamic Nucleus |
| Zdroj: | Experimental neurology. 102(1) |
| ISSN: | 0014-4886 |
| Popis: | The A1 noradrenergic cell group in the caudal ventrolateral medullary reticular formation of the rat sends efferent projections to a number of regions in the basal forebrain and hypothalamus, but the extent to which these projections represent collateral branches of individual axons is not known. Immunohistochemical labeling of medullary neurons containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine β-hydroxylase, and phenylethanolamine N-methyltransferase was used to reveal the anatomical location of A1 noradrenergic neurons within the ventrolateral medulla. Subsequently, the retrograde fluorescence double-labeling technique was employed to investigate the collateralization of ascending A1 efferent axons. The subcommissural bed nucleus of the stria terminalis (BST) was injected with rhodamine-fluorescent latex microspheres and the ipsilateral left paraventricular nucleus of the hypothalamus (PVN) was injected with Fast blue. Within the ventrolateral medulla, single- and double-labeled neurons were identified in a distribution corresponding to that demonstrated for A1 noradrenergic perikarya. The results indicate that some ascending axons from cells within the A1 region collateralize to effect a simultaneous innervation of the BST and PVN. The innervation of multiple efferent targets by single neurons within the A1 region may have inportant implications with respect to A1's postulated role in central cardiovascular regulation. |
| Databáze: | OpenAIRE |
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