Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity
Autor: | Joanna Szafraniec-Szczęsny, Szczepan Zapotoczny, Hassan Kassassir, Cezary Watala, Maria Wróbel, Małgorzata Janik-Hazuka, Kamil Kamiński, Marta Kaczor-Kamińska, Aleksandra Kmak |
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Rok vydání: | 2021 |
Předmět: |
Lysis
General Chemical Engineering sulfane sulfur Garlic Oil 02 engineering and technology Article Nanocapsules oil-core nanocapsules 03 medical and health sciences chemistry.chemical_compound hyaluronic acid Hyaluronic acid medicine sulfurtransferases General Materials Science glutathione QD1-999 030304 developmental biology 0303 health sciences garlic oil Chemistry Diallyl disulfide diallyl disulfide diallyl trisulfide 021001 nanoscience & nanotechnology Red blood cell medicine.anatomical_structure Diallyl trisulfide drug delivery Drug delivery Biophysics encapsulation 0210 nano-technology |
Zdroj: | Nanomaterials Volume 11 Issue 5 Nanomaterials, Vol 11, Iss 1354, p 1354 (2021) |
ISSN: | 2079-4991 |
Popis: | Diallyl disulfide (DADS) and diallyl trisulfide (DATS) are garlic oil compounds exhibiting beneficial healthy properties including anticancer action. However, these compounds are sparingly water-soluble with a limited stability that may imply damage to blood vessels or cells after administration. Thus, their encapsulation in the oil-core nanocapsules based on a derivative of hyaluronic acid was investigated here as a way of protecting against oxidation and undesired interactions with blood and digestive track components. The nuclear magnetic resonance (1H NMR) technique was used to follow the oxidation processes. It was proved that the shell of the capsule acts as a barrier limiting the sulfur oxidation, enhancing the stability of C=C bonds in DADS and DATS. Moreover, it was shown that the encapsulation inhibited the lysis of the red blood cell membrane (mainly for DADS) and interactions with serum or digestive track components. Importantly, the biological functions and anticancer activity of DADS and DATS were preserved after encapsulation. Additionally, the nanocapsule formulations affected the migration of neoplastic cells—a desirable preliminary observation concerning the inhibition of migration. The proposed route of administration of these garlic extract components would enable reaching their higher concentrations in blood, longer circulation in a bloodstream, and thus, imply a better therapeutic effect. |
Databáze: | OpenAIRE |
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