The clinical significance and primary determinants of hirsutism in patients with polycystic ovary syndrome
| Autor: | Efstathios Papadakis, Konstantinos Tziomalos, Ilias Katsikis, Christos Vosnakis, Eleni A. Kandaraki, Dimitrios Panidis, Panagiotis Chatzis, Elena Tsourdi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Hirsutism medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Overweight Body Mass Index Young Adult Endocrinology Internal medicine medicine Humans education Abdominal obesity hirsutism education.field_of_study Free androgen index business.industry Hyperandrogenism Age Factors General Medicine medicine.disease Polycystic ovary Obesity Abdominal Androgens Female Waist Circumference medicine.symptom business Body mass index Polycystic Ovary Syndrome |
| Zdroj: | European Journal of Endocrinology. 168:871-877 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectiveHirsutism is frequently present in patients with polycystic ovary syndrome (PCOS) and is a major sign of hyperandrogenism. However, other disorders frequently present in PCOS, particularly abdominal obesity and insulin resistance (IR), have also been implicated in the development of hirsutism in this population but relevant data are limited. We aimed to define the determinants of the presence of hirsutism in PCOS.DesignObservational study.MethodsWe studied 1297 patients with PCOS (age 24.3±5.8 years, BMI 26.8±6.9 kg/m2). Hirsutism was defined as a modified Ferriman–Gallwey score ≥8.ResultsWomen with hirsutism were younger, had greater BMI, and had higher levels of circulating androgens than women without hirsutism; markers of IR did not differ between the two groups after adjustment for age and BMI. The prevalence of hirsutism progressively declined with age, was lower in normal-weight women than in overweight and obese women, and was comparably prevalent in the hyperandrogenemic phenotypes of PCOS. In binary logistic regression analysis, independent predictors of the presence of hirsutism were younger age, larger waist circumference (W), and higher serum testosterone levels. In stepwise linear regression analysis, the Ferriman–Gallwey score independently correlated with age, W, free androgen index, and serum Δ4-androstenedione and DHEAS levels.ConclusionsBesides hyperandrogenemia, abdominal obesity, and young age are independently associated with the presence of hirsutism. In contrast, the relationship between IR and hirsutism appears to be mediated by the more severe obesity of insulin-resistant patients with PCOS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|