Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
| Autor: | Shahram Paydar, Babak Bagheri, Mahsa Khanlari, Yahya Daneshbod, Reza Vojdani, Mohammad Mohammadianpanah |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Male
Conjunctival Neoplasm Pathology medicine.medical_specialty Conjunctiva Lymphoma Oncogene Proteins Fusion lcsh:Medicine Gene Expression Case Report Conjunctival Neoplasms Lymphoma Mantle-Cell Translocation Genetic General Biochemistry Genetics and Molecular Biology SOXC Transcription Factors Cyclin D1 Antigens CD immune system diseases hemic and lymphatic diseases medicine Humans lcsh:Science (General) lcsh:QH301-705.5 CD20 Medicine(all) Mantle cell lymphoma biology Biochemistry Genetics and Molecular Biology(all) lcsh:R General Medicine Middle Aged medicine.disease Marginal zone medicine.anatomical_structure lcsh:Biology (General) Proto-Oncogene Proteins c-bcl-2 t(11 14) SOX 11 biology.protein CD5 Orbit lcsh:Q1-390 |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 5, Iss 1, p 671 (2012) |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/1756-0500-5-671 |
| Popis: | Background To describe a rare manifestation of mantle cell lymphoma (MCL) in conjunctiva, with clinical, hisologic, immunohistologic and genetic findings together with review of the Literature. Case presentation Most ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as right conjunctival mass of at least three months duration in a 64-year-old man. Histopathologic examination showed a proliferation of monomorphous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. By immunohistochemistry, the infiltrate was positive for CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11. Fluorescent in situ hybridization demonstrated the presence of IGH-CCND1 fusion indicating t(11;14). Conclusion A rigorous approach to initial diagnosis and staging of small cell lymphomas of the ocular adnexa is needed. The recognition of ocular MCL requires appropriate immunohistochemical staining and/or genetic confirmation to differentiate this rare form of presentation of MCL from other more frequent small cell lymphomas. |
| Databáze: | OpenAIRE |
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