Investigating a new neuromodulation treatment for brain disorders using synchronized activation of multimodal pathways
| Autor: | Benjamin T. Smith, Cory D. Gloeckner, Hubert H. Lim, Markovitz Craig |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Guinea Pigs
Stimulation Somatosensory system Article Tinnitus 03 medical and health sciences 0302 clinical medicine Neuroplasticity Animals Humans Medicine Auditory system 030304 developmental biology Neurons Brain Diseases Neurotransmitter Agents 0303 health sciences Neuronal Plasticity Multidisciplinary business.industry Hyperacusis Brain Somatosensory Cortex Combined Modality Therapy Electric Stimulation Neuromodulation (medicine) medicine.anatomical_structure Acoustic Stimulation Somatosensory evoked potential medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Neuromodulation is an increasingly accepted treatment for neurological and psychiatric disorders but is limited by its invasiveness or its inability to target deep brain structures using noninvasive techniques. We propose a new concept called Multimodal Synchronization Therapy (mSync) for achieving targeted activation of the brain via noninvasive and precisely timed activation of auditory, visual, somatosensory, motor, cognitive and limbic pathways. In this initial study in guinea pigs, we investigated mSync using combined activation of just the auditory and somatosensory pathways, which induced differential and timing dependent plasticity in neural firing within deep brain and cortical regions of the auditory system. Furthermore, by varying the location of somatosensory stimulation across the body, we increased or decreased spiking activity across different neurons. These encouraging results demonstrate the feasibility of systematically modulating the brain using mSync. Considering that hearing disorders such as tinnitus and hyperacusis have been linked to abnormal and hyperactive firing patterns within the auditory system, these results open up the possibility for using mSync to decrease this pathological activity by varying stimulation parameters. Incorporating multiple types of pathways beyond just auditory and somatosensory inputs and using other activation patterns may enable treatment of various brain disorders. |
| Databáze: | OpenAIRE |
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