EFFECTS OF ASCORBIC ACID ON HEALTH PARAMETERS IN GUINEA PIGS
| Autor: | A. V. Rao, E. Bright-See, A. R. Ten Cate, M. J. Veen-Baigent |
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| Rok vydání: | 1975 |
| Předmět: |
Male
Proline Iron Guinea Pigs Glycine Serum copper Ascorbic Acid General Biochemistry Genetics and Molecular Biology Hemoglobins Animal science Ascorbic acid intake History and Philosophy of Science Animals Phospholipids Wound Healing Dose-Response Relationship Drug Chemistry General Neuroscience Body Weight Absolute level Organ Size Ascorbic acid Hydroxyproline Cholesterol Hematocrit Organ Specificity Ascorbic Acid Deficiency Saturation (chemistry) Tooth Dose response data |
| Zdroj: | Annals of the New York Academy of Sciences. 258:339-354 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.1975.tb29294.x |
| Popis: | The maximal response of a selection of ascorbic-acid-dependent parameters to a range of intakes of ascorbic acid has been shown to occur at virtually one level of intake in the present experiments. Further, this response occurred with intakes that produced only 1/2 saturation or less of tissues with ascorbic acid. Excessive intakes did not enhance effects, and, as in the case of serum copper levels, may have a detrimental effect. In view of the known factors that may influence requirements and the intralaboratory variability in experimental conditions, the more reasonable approach to the interpretation of dose response data is likely to relate the response to the accompanying degree of tissue saturation, rather than to an absolute level of ascorbic acid intake. |
| Databáze: | OpenAIRE |
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