Acute interactions between l-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice
| Autor: | Carine Cleren, Catherine Vilpoux, Nathalie Dourmap, J.-J. Bonnet, Jean Costentin |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
1-Methyl-4-phenylpyridinium medicine.medical_specialty Levodopa Neurotoxins Hypothalamus Mice Norepinephrine chemistry.chemical_compound Vesicular Biogenic Amine Transport Proteins Internal medicine medicine Animals Drug Interactions Oxidopamine Molecular Biology Injections Intraventricular Analysis of Variance Neurotransmitter Agents Hydroxydopamine Membrane Glycoproteins Benserazide General Neuroscience Neuropeptides Neurotoxicity Membrane Transport Proteins Biological Transport medicine.disease Vesicular monoamine transporter Endocrinology nervous system chemistry Vesicular Monoamine Transport Proteins Toxicity Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 830:314-319 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(99)01420-1 |
| Popis: | We have compared the effects of an i.p. pretreatment with L-DOPA (200 mg/kg) associated with benserazide (25 mg/kg) on neurotoxic effects of either 6-hydroxydopamine (6-OHDA) (50 microg, 10 microl per mouse) or 1-methyl-4-phenylpyridinium (MPP+) (17.5 microg, 10 microl per mouse). The striatal dopamine (DA) content, the vesicular monoamine transporter (VMAT2) density, as well as the hypothalamic norepinephrine (NE) content were measured 8 days after treatments. The L-DOPA-benserazide pretreatment worsened by 65% the 6-OHDA-induced depletion in striatal DA. On the contrary, it reduced by 42% the MPP+-induced depletion in striatal DA and by 54% the MPP+-induced decrease in VMAT2 density. It was noticed that the L-DOPA-benserazide pretreatment did not modify the marked decrease in hypothalamic NE content induced by 6-OHDA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect