A simple visual immunoassay (VIA) for rapid identification of high lipoprotein(a) blood levels
| Autor: | Luis Sorell Gómez, Gertrudis Rojas |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B Clinical Biochemistry Enzyme-Linked Immunosorbent Assay Biochemistry chemistry.chemical_compound Internal medicine medicine Humans Immunoassay Immunoradiometric assay biology medicine.diagnostic_test Biochemistry (medical) Antibodies Monoclonal Radioimmunoassay General Medicine Lipoprotein(a) Endocrinology chemistry Low-density lipoprotein biology.protein Immunoradiometric Assay lipids (amino acids peptides and proteins) Antibody Lipoprotein |
| Zdroj: | Clinica Chimica Acta. 260:65-71 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/s0009-8981(96)06500-x |
| Popis: | Lipoprotein(a) (Lp(a)), is a low density lipoprotein (LDL)-like lipoprotein that contains a highly hydrophilic glycoprotein named apolipoprotein(a) (apo(a)), which is covalently linked to the apolipoprotein B-100 (apo B-100), by a disulfide bridge [1]. Numerous studies have shown that an elevated plasma level of Lp(a) is a major independent risk factor for atherosclerosis and cardiovascular diseases [2-5]. Several authors have determined that individuals with Lp(a) blood concentration above a critical pathological threshold of 300 mg/1 have two to three times higher risk for premature coronary artery disease and myocardial or cerebral infarction [6-8]. Lp(a) has been measured quantitatively by electroimmunoassay, radioimmunoassay, immunoturbidimetric assays and immunoenzymatic assays [9]. All these methods require laboratory equipment and are time-consuming |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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