Long-term effect of Haart on biochemical profiles of HIV/AIDS patients in a tertiary health facility in Benin city, Nigeria
| Autor: | Patrick O Erah, Shakirat I. Bello, Abel N Onunu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pediatrics Aids patients Creatinine business.industry virus diseases Pharmaceutical Science Biochemical parameters HIV/AIDS Long-term HAART Quality of life (QoL) medicine.disease Antiretroviral therapy Gastroenterology chemistry.chemical_compound Acquired immunodeficiency syndrome (AIDS) Quality of life chemistry Internal medicine medicine Benin city Pharmacology (medical) Term effect business TBIL |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol 13, No 11 (2014); 1941-1946 |
| ISSN: | 1596-5996 1596-9827 |
| Popis: | Purpose : To assess the long-term effect of highly active antiretroviral therapy (HAART) on biochemical parameters of HIV-infected patients in University of Benin Teaching Hospital (UBTH), Benin City, Nigeria. Methods : HIV/AIDS patients on HAART for 2 - 8 years (297), those who were not on HAART (112, positive control), and healthy subjects (103, negative control) were recruited in the Infectious Diseases Clinic (IDC) of UBTH. Their sera were assayed for biochemical parameters. WHOQoL bref instrument was used to assess patients’ Quality of life (QoL). Results : Patients who have been on HAART had significantly elevated ALT and AST levels (p < 0.001) but mild liver toxicity. QoL of these patients was not significantly different from that of the healthy controls. The levels of Na + (133.4 ± 5.2 mmol/l), K + (3.6 ± 0.4 mmol/l) and Cl - (101.3 ± 4.0 mmol/l) were significantly lower in patients on HAART than those of the positive (137.5 ± 5.1, 3.9 ± 0.5, 104.3 ± 5.7 mmol/l respectively, p < 0.001). Also, levels of creatinine (0.8 ± 0.2 mg/dl), TBil (0.5 ± 0.2 mg/dl), and CB (0.3 ± 0.5 mg/dl) were significantly higher in patients on HAART than those of either the positive (0.7 ± 0.3, 0.4 ± 0.2, 0.2 ± 0.1 mg/dl) or negative (0.7 ± 0.3, 0.3 ± 0.1, 0.2 ± 0.1 mg/dl) controls respectively (p < 0.001). Conclusion : Treatment with HAART for 2 - 8 years may not produce severe hepatotoxicity in HIV/AIDS patient though mild liver toxicity should be expected. The patients’ QoL was not negatively affected by the use of HAART for 2 - 8 years. Keywords : Biochemical parameters, HIV/AIDS, Long-term HAART, Quality of life (QoL). |
| Databáze: | OpenAIRE |
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