Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats
| Autor: | Maria do Carmo Quevedo Santos, Carolina Kolberg, Jéssica Araújo de Souza, Andréa Horst, Wania Aparecida Partata, Adriane Belló-Klein, Taina Scheid, Ana Paula Konzen Riffel |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Nociception Pain Threshold 0301 basic medicine Vitamin Time Factors medicine.medical_treatment Ascorbic Acid Pharmacology Antioxidants Lipid peroxidation Sciatica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration Physical Stimulation medicine Animals Vitamin E Aspartate Aminotransferases Rats Wistar Pain Measurement Analgesics Analysis of Variance business.industry General Neuroscience Alanine Transaminase gamma-Glutamyltransferase Ascorbic acid Constriction Rats Disease Models Animal 030104 developmental biology chemistry Hyperalgesia Anesthesia Neuropathic pain Sciatic nerve medicine.symptom business Locomotion 030217 neurology & neurosurgery |
| Zdroj: | Brain Research Bulletin. 121:169-177 |
| ISSN: | 0361-9230 |
| Popis: | Antioxidants have been tested to treat neuropathic pain, and α-Tocopherol (vitamin E--vit. E) and ascorbic acid (vitamin C--vit. C) are potent antioxidants. We assessed the effect of intraperitoneal administration of vit. C (30 mg/kg/day) and vit. E (15 mg/kg/day), given alone or in combination, on the mechanical and thermal thresholds and the sciatic functional index (SFI) in rats with chronic constriction injury (CCI) of the sciatic nerve. We also determined the lipid hydroperoxides and total antioxidant capacity (TAC) in the injured sciatic nerve. Further, we assessed the effects of oral administration of vit. C+vit. E (vit. C+E) and of a combination of vit. C+E and gabapentin (100mg/kg/day, i.p.) on the mechanical and thermal thresholds of CCI rats. The vitamins, whether administered orally or i.p., attenuated the reductions in the mechanical and thermal thresholds induced by CCI. The antinociceptive effect was greater with a combination of vit. C+E than with each vitamin given alone. The SFI was also improved in vitamin-treated CCI rats. Co-administration of vit. C+E and gabapentin induced a greater antinociceptive effect than gabapentin alone. No significant change occurred in TAC and lipid hydroperoxide levels, but TAC increased (45%) while lipid hydroperoxides decreased (38%) in the sciatic nerve from vit. C+E-treated CCI rats. Thus, treatment with a combination of vit. C+E was more effective to treat CCI-induced neuropathic pain than vitamins alone, and the antinociceptive effect was greater with co-administration of vit. C+E and gabapentin than with gabapentin alone. |
| Databáze: | OpenAIRE |
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