TRPA1: a transducer and amplifier of pain and inflammation
| Autor: | Niina Jalava, Timo Korjamo, Ari Koivisto, Ken Lindstedt, Marja Saarnilehto, Hugh Chapman, Antti Pertovaara |
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| Rok vydání: | 2013 |
| Předmět: |
Ankyrins
Pain Sensory system Toxicology 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine Transient Receptor Potential Channels Oximes Noxious stimulus medicine Animals Humans Plant Oils Acrolein 030304 developmental biology Pharmacology Inflammation 0303 health sciences Neurogenic inflammation Aldehydes Chemistry Chronic pain food and beverages General Medicine Spinal cord medicine.disease 3. Good health Nociception medicine.anatomical_structure Spinal Cord Purines Anesthesia Axon reflex Acetanilides Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Mustard Plant |
| Zdroj: | Basicclinical pharmacologytoxicology. 114(1) |
| ISSN: | 1742-7843 |
| Popis: | The transient receptor potential ankyrin 1 (TRPA1) ion channel on peripheral terminals of nociceptive primary afferent nerve fibres contributes to the transduction of noxious stimuli to electrical signals, while on central endings in the spinal dorsal horn, it amplifies transmission to spinal interneurons and projection neurons. The centrally propagating nociceptive signal that is induced and amplified by TRPA1 not only elicits pain sensation but also contributes to peripheral neurogenic inflammation through a peripheral axon reflex or a centrally mediated back propagating dorsal root reflex that releases vasoactive agents from sensory neurons in the periphery. Endogenous TRPA1 agonists that are generated under various pathophysiological conditions both in the periphery and in the spinal cord have TRPA1-mediated pro-nociceptive and pro-inflammatory effects. Among endogenous TRPA1 agonists that have been shown to play a role in the pathogenesis of pain and inflammatory conditions are, for example, methylglyoxal, 4-hydroxynonenal, 12-lipoxygenase-derived hepoxilin A3, 5,6-epoxyeicosatrienoic acid and reactive oxygen species, while mustard oil and cinnamaldehyde are most commonly used exogenous TRPA1 agonists in experimental studies. Among selective TRPA1 antagonists are HC-030031, A-967079, AP-14 and Chembridge-5861528. Recent evidence indicates that TRPA1 plays a role also in transition of acute to chronic pain. Due to its location on a subpopulation of pain-mediating primary afferent nerve fibres, blocking the TRPA1 channel is expected to have antinociceptive, antiallodynic and anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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