Quantitative Trait Loci Affecting Liver Fat Content in Mice
| Autor: | Jane P. Kenney-Hunt, Gloria L. Fawcett, Olga Minkina, Clay F. Semenkovich, James M. Cheverud |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
nonalcoholic fatty liver disease
Male medicine.medical_specialty Cirrhosis QTL Quantitative Trait Loci Population 030209 endocrinology & metabolism LG/J Investigations Biology Diet High-Fat Fats Mice 03 medical and health sciences Liver disease 0302 clinical medicine Non-alcoholic Fatty Liver Disease NAFLD Internal medicine Nonalcoholic fatty liver disease Diabetes Mellitus Genetics medicine Animals Obesity education Diet Fat-Restricted Molecular Biology mouse Genetics (clinical) 030304 developmental biology 2. Zero hunger 0303 health sciences education.field_of_study SM/J medicine.disease 3. Good health Fatty Liver Endocrinology Liver Female Steatosis Steatohepatitis Metabolic syndrome |
| Zdroj: | G3: Genes|Genomes|Genetics |
| ISSN: | 2160-1836 |
| DOI: | 10.1534/g3.112.003343 |
| Popis: | Nonalcoholic fatty liver disease, a condition in which excess fat accumulates in the liver, is strongly associated with the metabolic syndrome, including obesity and other related conditions. This disease has the potential to progress from steatosis to steatohepatitis, fibrosis, and cirrhosis. The recent increase in the prevalence of the metabolic syndrome is largely driven by changes in diet and activity levels. Individual variation in the response to this obesogenic environment, however, is attributable in part to genetic variation between individuals, but very few mammalian genetic loci have been identified with effects on fat accumulation in the liver. To study the genetic basis for variation in liver fat content in response to dietary fat, liver fat proportion was determined using quantitative magnetic resonance imaging in 478 mice from 16 LG/J X SM/J recombinant inbred strains fed either a high-fat (42% kcal from fat) or low-fat (15% kcal from fat) diet. An analysis of variance confirmed that there is a genetic basis for variation in liver fat content within the population with significant effects of sex and diet. Three quantitative trail loci that contribute to liver fat content also were mapped. |
| Databáze: | OpenAIRE |
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