The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex-specifically regulated
| Autor: | Ennio Giordano, Ivana Peluso, Lino C. Polito, Dora Artiaco, Daniel Bopp, Giuseppe Saccone |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Gene isoform
Male animal structures Embryo Nonmammalian X Chromosome Transcription Genetic Transgene Molecular Sequence Data Polymerase Chain Reaction Evolution Molecular Sequence Homology Nucleic Acid Y Chromosome Animals Drosophila Proteins Blastoderm Amino Acid Sequence Drosophila (subgenus) Ceratitis Molecular Biology Gene Conserved Sequence Phylogeny Gene Library Genetics Sex Characteristics biology Phylogenetic tree Base Sequence Sequence Homology Amino Acid Diptera Gene Expression Regulation Developmental RNA-Binding Proteins Ceratitis capitata Sex Determination Processes biology.organism_classification Drosophila melanogaster Insect Hormones Female Musca Sequence Alignment Developmental Biology |
| Zdroj: | Development (Cambridge, England). 125(8) |
| ISSN: | 0950-1991 |
| Popis: | In Drosophila, Sxl functions as a binary switch in sex determination. Under the control of the primary sex-determining signal, it produces functional protein only in XX animals to implement female development. Here we report that, in contrast to Drosophila, the Sxl homologue in the Medfly, Ceratitis capitata, expresses the same mRNAs and protein isoforms in both XX and XY animals irrespective of the primary sex-determining signal. Also, experiments with two inducible transgenes demonstrate that the corresponding Ceratitis SXL product has no significant sex-transforming effects when expressed in Drosophila. Similar results have been obtained for the Sxl homologue of Musca domestica (Meise, M., Hilfiker-Kleiner, D., Brunner, C., Dübendorfer, A., Nöthiger, R. and Bopp, D. (1998) Development 125, 1487-1494). Our findings suggest that Sxl acquired its master regulatory role in sex determination during evolution of the Acalyptratae group, most probably after phylogenetic divergence of the genus Drosophila from other genera of this group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|