A fibrin based model for rheumatoid synovitis
| Autor: | Emilio Calvo, Gabriel Herrero-Beaumont, Jesús Egido, M A Alvarez-Soria, Olga Sánchez-Pernaute, Raquel Largo |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Fibrin deposition Immunology General Biochemistry Genetics and Molecular Biology Fibrin Arthritis Rheumatoid Pathogenesis Rheumatology Pannus Formation Synovitis Immunopathology Fibrinolysis medicine Humans Immunology and Allergy biology business.industry Hypothesis Blood Coagulation Disorders medicine.disease Coagulation biology.protein business |
| Zdroj: | Annals of the Rheumatic Diseases. 62:1135-1138 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2003.011767 |
| Popis: | Intracavitary fibrin clots may initiate pannus formation and the immunopathology of RA. Two critical steps, probably host dependent, may determine the development of RA: an altered regulation of extravascular haemostasis or an aberrant reactivity of synovial fibroblasts to the adhered fibrin clots. Current treatments for RA target events downstream of fibrin deposition, perhaps agents acting at an earlier stage should be tried. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|