Management of low-grade cervical cytology in young women. Cohort study from Denmark
| Autor: | Dorthe Ejersbo, Berit Andersen, Gry St-Martin, Jette Christensen, Lise Holst Thamsborg, Kirsten Marie Jochumsen, Elsebeth Lynge, Marianne Waldstrøm, Lise Grupe Larsen, Tonje Johansen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Denmark LSIL Uterine Cervical Neoplasms Atypical Squamous Cells Cervical cancer screening Sensitivity and Specificity 030218 nuclear medicine & medical imaging Cohort Studies 03 medical and health sciences 0302 clinical medicine Unknown Significance Cytology medicine Humans Radiology Nuclear Medicine and imaging Papillomaviridae Vaginal Smears Gynecology business.industry Papillomavirus Infections fungi Cervical cytology Hematology General Medicine medicine.disease female genital diseases and pregnancy complications ASCUS stomatognathic diseases Squamous intraepithelial lesion Oncology 030220 oncology & carcinogenesis Female business Ascus Cohort study |
| Zdroj: | St-Martin, G, Thamsborg, L H, Andersen, B, Christensen, J, Ejersbo, D, Jochumsen, K, Johansen, T, Larsen, L G, Waldstrøm, M & Lynge, E 2021, ' Management of low-grade cervical cytology in young women. Cohort study from Denmark ', Acta Oncologica, vol. 60, no. 4, pp. 444-451 . https://doi.org/10.1080/0284186X.2020.1831061 St-Martin, G, Thamsborg, L H, Andersen, B, Christensen, J, Ejersbo, D, Jochumsen, K, Johansen, T, Larsen, L G, Waldstrøm, M & Lynge, E 2021, ' Management of low-grade cervical cytology in young women : Cohort study from Denmark ', Acta Oncologica, vol. 60, no. 4, pp. 444-451 . https://doi.org/10.1080/0284186X.2020.1831061 |
| Popis: | OBJECTIVE: Cytology findings of atypical squamous cells of unknown significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) are common among women under 30, but evidence on best management strategy is insufficient. We therefore investigated how different management strategies used in Denmark influenced biopsy rates and detection of cervical intraepithelial neoplasia (CIN).METHODS: Register-based cohort study including Danish women aged less than 30 years and born 1980-95, with ASCUS/LSIL as their first abnormal cervical cytology in 2008-16. Rates and relative risks (RR) of biopsy and detection of CIN3+, CIN2 and RESULTS: 19,946 women with ASCUS and 19,825 with LSIL were included in the study of whom 92% had adequate information about follow-up. Among women referred directly to biopsy, CIN3+ was detected among 21%, CIN2 in 17%, while 62% had CONCLUSIONS: The choice of management strategy influences both the detection rate for severe lesions (CIN3+) and the proportion of women followed up for potentially insignificant findings. |
| Databáze: | OpenAIRE |
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