Disappearance of Terminal Deoxynucleotidyltransferase in Human Malignant T-Lymphoblasts Treated with a Human Alpha Interferon Preparation
| Autor: | Hiromu Nakamura, Saeko Takano, Haruhisa Mita, Yasuiti Nagano |
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| Rok vydání: | 1984 |
| Předmět: |
endocrine system
T-Lymphocytes Immunology Cell Alpha interferon Biology Microbiology Cell Line DNA Nucleotidylexotransferase Interferon Virology medicine Humans Cell growth Lymphoblast Molecular biology Leukemia Lymphoid stomatognathic diseases medicine.anatomical_structure Terminal deoxynucleotidyl transferase Cell culture DNA Nucleotidyltransferases Interferon Type I Cell Division Interferon type I medicine.drug |
| Zdroj: | Microbiology and Immunology. 28:1111-1115 |
| ISSN: | 0385-5600 |
| DOI: | 10.1111/j.1348-0421.1984.tb00768.x |
| Popis: | Human T-lymphoblastoid cell lines RPMI 8402, MOLT-3, and CCRF-CEM were treated with interferon (IFN) to determine if the treatment would result in the disappearance of cellular terminaldeoxynucleotidyltransferase (TdT), a possible differentiation marker for T-lymphocytes. Incubation of RPMI 8402 cells in the presence of IFN preparation caused a decrease in the number of TdT-positive cells and in TdT activity of the cell extract. The inhibition of cell multiplication was dose dependent. The anticellular effect of IFN preparation was cytostatic, not cytocidal. The IFN preparation modified neither the TdT content nor proliferation of MOLT-3 and CCRF-CEM cell lines. The effects of IFN preparation thus varied with the cell line. |
| Databáze: | OpenAIRE |
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