Drug‐eluting stent coatings
| Autor: | Robert A. Hoerr, Steven P. Schmidt, Chris Frethem, M. Michelle Evancho-Chapman, Greg Haugstad, John D. Foley, Judit E. Puskas, Lyn G. Muñoz-Robledo, Jinping Dong |
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| Rok vydání: | 2009 |
| Předmět: |
Materials science
Polymers medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Stent Biocompatible Materials Drug-Eluting Stents Bioengineering Arborescent engineering.material Biocompatible material Clinical Practice Coating Drug-eluting stent Coronary stent medicine engineering Humans Nanotechnology Thermoplastic elastomer Biomedical engineering |
| Zdroj: | WIREs Nanomedicine and Nanobiotechnology. 1:451-462 |
| ISSN: | 1939-0041 1939-5116 |
| Popis: | This paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug-eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Our group has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D_SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc.™) was used to coat test coupons and coronary stents with selected DSIBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release profiles were influenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer-drug mixture. Copyright © 2009 John Wiley & Sons, Inc. For further resources related to this article, please visit the WIREs website. |
| Databáze: | OpenAIRE |
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