High amounts of SARS-CoV-2 precede sickness among asymptomatic healthcare workers
| Autor: | Cecilia Hellström, Johan Mattsson, Laila Sara Arroyo Mühr, My Hedhammar, Emilie Hultin, Eni Andersson, K. Miriam Elfström, Jennie Olofsson, Sadaf Sakina Hassan, Maike Seifert, Marica Hamsten, Fredrik Boulund, Sofia Bergström, Elisa Pin, Peter Nilsson, Camilla Lagheden, Joakim Dillner, Anna Månberg, Jonas Blomqvist, Sophia Hober, Sara Nordqvist-Kleppe, Lars Engstrand, Mathias Uhlén, Carina Eklund, Kalle Conneryd Lundgren, Ville Pimenoff, August Jernbom Falk |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Health Personnel sick leave 030204 cardiovascular system & hematology Antibodies Viral Asymptomatic Polymerase Chain Reaction Serology Hospitals University 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Major Article Immunology and Allergy antibodies Humans Mass Screening Serologic Tests 030212 general & internal medicine Young adult Mass screening Aged Sweden business.industry SARS-CoV-2 healthcare workers Absolute risk reduction COVID-19 Odds ratio Middle Aged Confidence interval Coronavirus Infectious Diseases AcademicSubjects/MED00290 Sick leave Asymptomatic Diseases Disease Progression RNA Viral Female medicine.symptom business |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity among asymptomatic subjects reflects past or future disease may be difficult to ascertain. Methods We tested 9449 employees at Karolinska University Hospital, Stockholm, Sweden for SARS-CoV-2 RNA and antibodies, linked the results to sick leave records, and determined associations with past or future sick leave using multinomial logistic regression. Results Subjects with high amounts of SARS-CoV-2 virus, indicated by polymerase chain reaction (PCR) cycle threshold (Ct) value, had the highest risk for sick leave in the 2 weeks after testing (odds ratio [OR], 11.97; 95% confidence interval [CI], 6.29–22.80) whereas subjects with low amounts of virus had the highest risk for sick leave in the 3 weeks before testing (OR, 6.31; 95% CI, 4.38–9.08). Only 2.5% of employees were SARS-CoV-2 positive while 10.5% were positive by serology and 1.2% were positive in both tests. Serology-positive subjects were not at excess risk for future sick leave (OR, 1.06; 95% CI, .71–1.57). Conclusions High amounts of SARS-CoV-2 virus, as determined using PCR Ct values, was associated with development of sickness in the next few weeks. Results support the concept that PCR Ct may be informative when testing for SARS-CoV-2. Clinical Trials Registration. NCT04411576. |
| Databáze: | OpenAIRE |
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